NEW YORK - Betrayed by his big serve, 2003 champion Andy Roddick lost to Novak Djokovic 6-2, 6-3, 3-6, 7-6 (5) in the U.S. Open quarterfinals Thursday night.

Two points from forcing a fifth set at 5-4 in the fourth, Roddick double-faulted twice in a row and was broken for the fifth time - twice more than he lost serve in his first four matches combined.

The third-seeded Djokovic, the reigning Australian Open champion, advanced to a semifinal meeting against Roger Federer. It's a rematch of last year's U.S. Open final, which Federer won for his fourth consecutive title at Flushing Meadows.

Federer beat qualifier Gilles Muller 7-6 (5), 6-4, 7-6 (5) Thursday, extending his own record by reaching the semifinals at an 18th consecutive Grand Slam tournament.

“He created a monster, like he said a couple years ago. He won everything. And now everybody expects him to win everything, and, I mean, he's also just human,” Muller said. “Even today ... you could still see why he was No. 1 - and still No. 2 now. Every time the score was tied, he came up with a better shot.”

It was Federer's 32nd straight victory at the U.S. Open, where he has won the past four championships. The only man to have won more matches or titles in a row at this tournament was Bill Tilden in the 1920s.

Federer spoke proudly of his run of major semifinals; no other man ever topped 10.

“A huge streak,” he said. “I hope this time around I can take it a step further than I did in Paris or Wimbledon.”

See? Even he focuses on his missteps, making reference there to his losses to Rafael Nadal in the past two Grand Slam finals.

Bidding for a 13th major title, which would move him one shy of Pete Sampras' record, Federer will meet No. 3 Novak Djokovic in the semifinals.

The other men's semifinal is No. 1 Nadal vs. No. 6 Andy Murray.

In the women's semifinals Friday, two-time champion Serena Williams faces Dinara Safina, and Jelena Jankovic meets Elena Dementieva. One of the four will move up to No. 1 in the rankings after the tournament.

Federer spent a record 237 consecutive weeks atop the rankings from February 2004 until last month, when Nadal supplanted him. That's only one of several streaks Federer has seen snapped in 2008.

He reached a record 10 consecutive major finals, until losing to Djokovic in the Australian Open semifinals in January. He won a record-tying five consecutive Wimbledon titles, until losing a 9-7 fifth set to Nadal in near-darkness in July. He was seeded No. 1 at 18 consecutive Grand Slam tournaments, until Nadal relegated him to No. 2 at this one.

“There's a lot at stake for him, obviously, as far as, you know, not having won a major this year and losing a No. 1 ranking. So he seems to be obviously very focused and is playing better,” said Patrick McEnroe, the U.S. Davis Cup captain who also is coaching Roddick.

“I don't think he's playing quite at the level that he was in the last couple years,” McEnroe added, “but he's certainly capable of turning it around.”

Federer did exactly that in the final tiebreaker against Muller. Trailing 4-1, Federer took six of the final seven points, including a cross-court backhand passing shot to get to match point. It was the sort of spectacular stroke Federer often produces, but he marked this one with a loud shout of “Come on!”

When Muller put a backhand into the net on the next point, the tighter-than-expected match was over and Federer finally could leap in the air and scream again.

He let out several yelps during the afternoon, sometimes in anger, sometimes in delight, and sometimes it was tough to understand in which language (Swiss German, French or English). Once, he let out a high-pitched “Woooo!”

A more combustible Federer has been on display throughout this U.S. Open. A less overpowering Federer has been on display throughout this season.

“I guess for a while I put my head down in the matches and just tried to keep that unbelievable run I had going instead of trying to disturb myself with, you know, any sort of reactions really,” he acknowledged.

“Who knows? Maybe it is just a couple of weeks, and I'm going crazy, and after that you'll see me more relaxed again.”

He insisted afterward that he was frustrated more by the wind and sun in Arthur Ashe Stadium than by his inability to take advantage of any of the first six set points he earned in the opener. Or by the 10 break points he wasted in the match.

Muller's assessment of both men's play?

“The level was not that high,” he said.

Muller dropped to 0-1 in Grand Slam quarterfinals, while Federer is 20-2.

Past performances aside, Muller felt as though he could win, which isn't necessarily how most opponents approached matches against Federer in recent years.

“On the court, nobody should have respect for him. You just go out there to win, no matter who is on the other side of the court,” Muller said, adding a few moments later: “A lot of people think that I should be happy, but actually I'm disappointed, because I think today I had my chances - and I didn't take them.”