NEW YORK - Brooke Astor was the grande dame of New York City society and philanthropy - a woman as comfortable in a Harlem youth center as she was in a Fifth Avenue penthouse.

She hobnobbed with the queen of England and showed up on the streets of drug-ravaged neighborhoods to donate her fortune. In the course of her rarefied existence, she gave away nearly $200 million.

Her life's motto summed up her prodigious generosity in nine words: “Money is like manure, it should be spread around.”

One of city's most recognized ladies, Astor, 105, died Monday of pneumonia at Holly Hill, her Westchester County estate, family lawyer Kenneth Warner said.

Her death reverberated throughout New York - and beyond.

“Brooke was a great philanthropist, and a great lady, and we'll not see the likes of her again,” said former first lady Nancy Reagan, noting that Astor “was very close to my entire family.”

“I've known her since I was 14,” said Reagan. “In fact, when my mother died, Brooke told me, ‘I know no one can replace your mother, Nancy, but I'd like to try.”'

Gov. Eliot Spitzer called Astor a true philanthropist who “devoted her time to improving the lives of all New Yorkers, and specifically underprivileged children.”

“Brooke was a truly remarkable woman and an irreplaceable friend,” longtime family friend David Rockefeller said. “She was the leading lady of New York in every sense of the word.”

Although a legendary figure in New York City and feted with a famous gala on her 100th birthday in March 2002, Astor was mostly interested in putting the fortune that husband, Vincent Astor, left to use where it would do the most to alleviate human misery.

Her efforts won her a Presidential Medal of Freedom, the nation's highest civilian honor, in 1998.

Brooke Astor gave millions of dollars to what she called the city's “crown jewels” - among them the New York Public Library, Carnegie Hall, the Museum of Natural History, Central Park, the Bronx Zoo and the Metropolitan Museum of Art, where the flags were lowered to half-staff after her death.

But she also funded scores of smaller projects: Harlem's Apollo Theater; a new boiler for a youth center; beachside bungalow preservation; a church pipe organ; furniture for homeless families moving into apartments.

It was a very personal sort of philanthropy.

“People just can't come up here and say, 'We're doing something marvelous, send a check,”' she said. “We say, ‘Oh, yes, we'll come and see it.”'

The final year of Astor's life was marred by a nasty family feud over her care, including allegations that she was forced to sleep on a couch that smelled of urine while subsisting on a diet of pureed peas and oatmeal. Court papers said her beloved dogs Boysie and Girlsie were kept locked in a pantry.

The allegations emerged in July 2006 court documents that provided almost daily sensational headlines.

In a settlement three months later, her son, Anthony Marshall, was replaced as her legal guardian with Annette de la Renta, wife of the fashion designer Oscar de la Renta.

Marshall's son Philip Marshall, a professor at Roger Williams University in Rhode Island, had alleged that his father was looting her estate and allowing her to live in the filthy conditions at her Park Avenue duplex. Anthony Marshall, a former diplomat and Broadway producer who won Tony awards in 2003 and 2004, denied any wrongdoing.

In December, a Manhattan judge ruled that claims “regarding Mrs. Astor's medical and dental care and the other allegations of intentional elder abuse” by Anthony Marshall were not substantiated.

“I have lost my beloved mother, and New York and the world have lost a great lady,” Marshall said. “She was one of a kind in every way. Her tombstone will be inscribed with the words she specifically asked for: ‘I had a wonderful life.' I am thankful that she did. I will miss her deeply and always.”

The Vincent Astor Foundation was created when he died in 1959. Vincent Astor had no children; he left his widow $2 million plus the interest off $60 million and endowed the foundation with an additional $67 million.

The foundation gave away approximately $200 million by the time it closed at the end of 1997.

“I grew up feeling that the most important thing in life was to have good manners and to enhance the lives of others,” Brooke Astor said in a 1992 interview with The Associated Press.

She decided that since the money was made in New York it should largely be spent there. She also persuaded the trustees to give away principal as well as interest so most of the money would be spent in her lifetime.

“I'm afraid that, to old John Jacob Astor, spending principal would seem like dancing naked in the streets,” she acknowledged.

Her second marriage was to stockbroker Charles “Buddie” Marshall. Her son Anthony, from her marriage to Kuser, took Marshall's name. During her marriage to Marshall, Astor wrote articles for various magazines and joined the staff of House & Garden, where she was feature editor for several years.

Marshall died in 1952. A year later, she married Vincent Astor, the eldest son of John Jacob Astor 4th, who died in the sinking of the Titanic. Vincent Astor's great-great-grandfather John Jacob Astor made a fortune in fur trading and New York real estate.

“Vincent was a very suspicious man,” she recalled.

“The fact that he had total confidence in me to run the foundation made me want to vindicate him, show him - wherever he is - that I could do a good job.”

Hers was a hands-on approach, personally going over applications and then going out to meet the people who ran the programs to see what they were doing.

“Even in the worst drug areas, I don't hesitate to go right in and see people,” she once said.

Astor wrote four books: “Patchwork Child,” a 1962 autobiography; “The Bluebird is at Home,” 1965, a novel; the autobiographical “Footprints,” 1980; and “The Last Blossom on the Plum Tree,” 1986, a period novel.

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Associated Press writer Adam Goldman contributed to this report.